Extended Data Fig. 4: Selective dependencies in pediatric cell lines and the relationship to mutation burden.

a, Mutational burden count of mutations in whole exome sequencing (WES) (y-axis) compared to the number of selective dependencies per cell line (x-axis) in the screen. b, Mutational burden count of mutations in WES filtered to only include hotspot, missense or damaging mutations in COSMIC genes (y-axis) compared to the number of selective dependencies per cell line (x-axis) in the screen. c, Total number of genes with copy number alterations (CNA) (y-axis) compared to the number of selective dependencies per cell line (x-axis) in the screen. d, Total number of unique gene fusions (y-axis) compared to the number of selective dependencies per cell line (x-axis) in the screen. The circles in panels (a-d) represent individual cell lines with tumor types colored as in panel (e). The blue lines in panels (a-d) represent a linear model fit to this data with the gray shaded area representing the 95% confidence interval around the fit. e, Number of selective dependencies per cell line (y-axis) grouped by tumor type ordered by number of cell lines (x-axis). Each circle represents an individual cell line with pediatric tumors colored by type; the black line represents the median number of selective dependencies per tumor type.