Extended Data Fig. 4: Overlap between genome-wide significant brain shape loci and genome-wide significant loci from 430 other studies.

GWAS hits (number on x-axis) for other studies were obtained from the NCBI-EBI GWAS Catalog, and P-values (left, y-axis) and odds ratios (right, y-axis) for significance of overlap with regions in LD (> 0.2) with brain shape loci were computed using bedtools’ fisher function (see Methods). Note that relative to other traits with equivalent numbers of GWAS hits, face shape shows overlap with brain shape loci greater in both significance and magnitude.