Extended Data Fig. 8: SWI/SNF mutation and cancer.
a, Number of identified mutations in cancer from a curated set on non-redundant cancer studies (www.cbioportal.com) for the main SWI/SNF (red), ISWI (yellow), CHD (blue) and INO80 (green) ATPase subunits. b, Number of cancer types where the gene is considered a cancer driver gene (www.intogen.org) for the main SWI/SNF (red), ISWI (yellow), CHD (blue) and INO80 (green) ATPase subunits. c, Distribution of cancer-associated BRG1 mutations along the protein. Protein length (grey) and domains (colored squares) are drawn. Highly frequently and recurrently altered in cancer protein residues (cancer hotspots) are highlighted as orange dots in the upper track. K785R point mutation used in rescue experiments is indicated. d, Quantification of nuclear S9.6 signal intensity in HeLa (BRG1-proficient) and C-33 A (BRG1-deficient) cells. Data presented as scatter plot (n = 3). Scale bar, 10 μm. (Mann-Whitney U test, two-tailed). e, Number of identified mutations in cancer from a curated set on non-redundant cancer studies (www.cbioportal.com) for the main SWI/SNF genes. f, Number of cancer types where the gene is considered a cancer driver gene (www.intogen.org) for the main SWI/SNF genes. P-values are indicated. Other details as in Fig. 1.
