Extended Data Fig. 5: Radiotherapy-associated genomic scars linked to poor survival.

a, Left: Kaplan-Meier survival plot comparing overall survival time dependent on CDKN2A status at recurrence using two-sided log-rank test in IDH mutant glioma samples. Right: Multivariable cox regression model including CDKN2A status at recurrence, TMZ-treatment, molecular subtype and Age as variables. Two-sided Wald test was applied. b, Left: Kaplan Meier survival plot comparing survival time dependent on CDKN2A status at metastasis using two-sided log- rank test RT-treated metastases (n = 958 with available survival information). Middle: Kaplan Meier survival plot comparing survival time dependent on aneuploidy burden at metastasis using two-sided log-rank test in RT-treated metastases (n = 958 with available survival information). Samples were separated into 3 tertiles based on whole chromosome loss aneuploidy scores: high (top tertile), intermediate (middle tertile) and low (bottom tertile). Right: Kaplan Meier survival plot comparing survival time dependent RT signature ID8 burden at metastasis using two-sided log- rank test in RT-treated metastases (n = 958 with available survival information). Samples were separated into 3 tertiles based on ID8 burden: high (top tertile), intermediate (middle tertile) and low (bottom tertile). Note that a low ID8 burden is associated with better survival, indicating a better response to RT. c, Multivariable cox regression model including deletion burden at recurrence as continuous variable, CDKN2A homozygous deletion, Temozolomide-treatment, molecular subtype and age as variables in RT-treated IDH mutant samples.