Extended Data Fig. 5: Heatmap displaying effects of variants associating with birth weight and cardiovascular traits arranged by mode of transmission clusters.
From: Distinction between the effects of parental and fetal genomes on fetal growth
Variants associating with any of the three cardiovascular traits (SBP, hypertension or CAD) with P < 2.1 × 10−4 (0.05/number of independent variants (n = 243)) and a defined mode of transmission are shown. The effects, log(OR) or beta, were obtained from logistic or linear regression, respectively, of case/control status or trait values on genotype count of the sequence variant. The colors represent the effects of the 26 variants associating with the traits shown on the y-axis, with red indicative of a positive effect and blue of a negative effect. Effects are shown for the SBP increasing allele and variants are ordered first by their mode of transmission cluster classification and then by their effect on SBP. The effect is shown if the associating P-value is below 0.05. A filled circle represents P < 1 × 10−8 and an open circle P < 1 × 10−6. Transmission clusters: M, maternal effect; FM, fetal and maternal effect; FMN, no effect of the maternally transmitted allele; fM, fetal and maternal, with stronger maternal effect; Fm, fetal and maternal, with stronger fetal effect; PatT, paternally transmitted only effect; MatT, maternally transmitted only effect; F, fetal effect, independent of parent-of-origin. Birth weight (BW) phenotypes: BW mother and BW represent the corresponding meta-analyses, BWPT (paternally transmitted), BWMT (maternally transmitted) and BWMNT (maternally non-transmitted) are based on allele specific BW GWAS of Icelandic individuals and BWchild represents the Icelandic BW GWAS data. Abbreviations: SD, same direction; OD, opposite direction.
