Extended Data Fig. 6: Heatmap displaying the effects of PRSs for adult cardio-metabolic traits on fetal growth traits by different transmission modes.
From: Distinction between the effects of parental and fetal genomes on fetal growth
Effects are shown if P < 0.05, with positive associations represented in red and negative associations in blue. The P values and effects are from a linear regression of fetal trait values on PRS’s, adjusting for year of birth, gender and principal components. PRS for cardiovascular (CAD, hypertension and SBP), glycemic (T2D, HbA1c and glucose) and anthropometric (height, BMI and WHRadjBMI) traits were generated based on GWAS data from UK Biobank data for genotyped Icelandic individuals, and tested against the Icelandic fetal growth phenotypes. PRS for the transmitted and non-transmitted maternal (MT and MNT) and paternal (PT and PNT) alleles were tested separately using genotyped individuals only while Mother, Child and Father are based on the entire corresponding Icelandic GWAS data. The PRS were tested against birth weight, birth length, ponderal index, gestational age, as well as birth weight not adjusted for gestational age (BWunadjusted) and birth weight adjusted for birth length (BWadjBL).
