Extended Data Fig. 5: PRC2 target gene dynamics in H3.3-K27M mutant NSCs. | Nature Genetics

Extended Data Fig. 5: PRC2 target gene dynamics in H3.3-K27M mutant NSCs.

From: Simultaneous disruption of PRC2 and enhancer function underlies histone H3.3-K27M oncogenic activity in human hindbrain neural stem cells

Extended Data Fig. 5

a Gene ontology analysis of genes with unchanged (±0.1-fold) or reduced (>1.5-fold) SUZ12 binding in K27M-mutant NSC cultures. b Box plots presenting expression values for each of the indicated PRC2 target genes (Gaining SUZ12) in H3.3 WT or K27M mutant NSCs, n = 4 biologically independent samples. Box plots present median values and interquartile ranges (IQR), with whiskers representing quartiles 1/3 ± (1.5 × IQR) respectively.

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