Extended Data Fig. 8: Gene ontology analysis of differentially expressed genes associated with gene enhancer dynamics. | Nature Genetics

Extended Data Fig. 8: Gene ontology analysis of differentially expressed genes associated with gene enhancer dynamics.

From: Simultaneous disruption of PRC2 and enhancer function underlies histone H3.3-K27M oncogenic activity in human hindbrain neural stem cells

Extended Data Fig. 8

a. Waterfall plots presenting the log2 fold-change in ATAC-seq signal at all identified active enhancers (left) and active promoters (right) between WT and K27M-mutant NSC cultures. b. Gene ontology (GO) analysis of all genes associated with enhancer regions losing both H3K27ac signal and chromatin accessibility in K27M mutant NSCs (left). GO analysis of downregulated genes associated with enhancer regions losing both H3K27ac signal and chromatin accessibility (right). c. GO analysis of all genes associated with enhancer regions losing H3K27ac signal only in K27M mutant NSCs (left). GO analysis of downregulated genes associated with enhancer regions losing H3K27ac (right).

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