Extended Data Fig. 10: Transcriptional disruption in DIPG cell lines treated with compounds targeting chromatin regulators. | Nature Genetics

Extended Data Fig. 10: Transcriptional disruption in DIPG cell lines treated with compounds targeting chromatin regulators.

From: Simultaneous disruption of PRC2 and enhancer function underlies histone H3.3-K27M oncogenic activity in human hindbrain neural stem cells

Extended Data Fig. 10

RNA-seq volcano plots presenting the gene expression changes observed in an established H3.3-K27M mutant DIPG cell, DIPGXIII following treatment with Tazemetostat, JQ1, THZ1 or Panobinostat for 24 hours. Red and blue denotes genes significantly up and down-regulated, respectively in drug treated cultures.

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