Extended Data Fig. 5: HCR-FlowFISH and CASA reveal complex CRE sharing at the FADS locus. | Nature Genetics

Extended Data Fig. 5: HCR-FlowFISH and CASA reveal complex CRE sharing at the FADS locus.

From: Direct characterization of cis-regulatory elements and functional dissection of complex genetic associations using HCR–FlowFISH

Extended Data Fig. 5

a,b, Individual guide scores (points) and CASA CRE calls (bars) of HCR-FlowFISH screens for FADS1 (green), FADS2 (teal), and FADS3 (orange). K562 DHS (light blue) and H3K27ac (dark blue) peaks are also shown. Notably, these elements are shared between all three FADS genes. Surprisingly, perturbing the CRE in a results in a modest, but detectable, increase in FADS3 transcripts, in contrast to the decreases in FADS1 and FADS2 transcript abundance.

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