Extended Data Fig. 2: HDP mutational signature analysis of ESCC.

(a) 33 components extracted by HDP. (b) Average relative attributions of SBS COSMIC signatures and SV de novo signatures are broadly similar between all countries. Signatures accounting for less than 5% on average (with the exception of SBS3 and SBS16) are grouped together into the ‘Other’ category. (c) Comparison of average relative attribution of signatures between HDP and Sigprofiler.