Extended Data Fig. 3: DBS78 mutational signature analysis of ESCC. | Nature Genetics

Extended Data Fig. 3: DBS78 mutational signature analysis of ESCC.

From: Mutational signatures in esophageal squamous cell carcinoma from eight countries with varying incidence

Extended Data Fig. 3

(a) TMB plot showing the frequency and mutations/mb for each of the extracted DBS78 de novo signatures. (b) TMB showing the frequency and mutations/mb for each DBS78 COSMIC reference signature identified in the ESCC cohort. (c) Four de novo DBS78 signatures extracted from 552 ESCC cases. (d) Mapping of de novo signatures extracted from ESCC decomposed into COSMIC reference signatures. (e) COSMIC reference signatures identified in the ESCC cohort with known etiologies.

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