Fig. 1: Conditionally independent genome-wide significant hits.
From: Polygenic basis and biomedical consequences of telomere length variation
a, Manhattan plot curtailed at P < 1 × 10−50. We highlight the regions containing our 197 sentinel variants that are genome-wide significant (P < 8.31 × 10−9; horizontal dashed reference line) in the exact joint conditional model (Supplementary Table 1). We defined the region as known (blue) if a previous variant within 1 Mb of our sentinel has been reported at either genome-wide significance or at an FDR threshold of <5%. Regions were considered new (red) if a variant within 1 Mb of our sentinel that reached genome-wide significance was not previously identified. Non-significant variants are shown in either light or dark gray on alternate chomosomes. b, The estimated effect sizes (beta) against the P value from the GWAS analysis. c, Estimated effect sizes for the minor allele (beta) against the MAF from all participants in the GWAS.
