Extended Data Fig. 1: Association of GRS of diabetic complications with diabetes subtypes. | Nature Genetics

Extended Data Fig. 1: Association of GRS of diabetic complications with diabetes subtypes.

From: Genome-wide association analyses highlight etiological differences underlying newly defined subtypes of diabetes

Extended Data Fig. 1

a-e, Association of GRS for chronic kidney disease (CKD) (a), estimated glomerular filtration rate (eGFR) (b), urine albumin creatinine ratio (UACR) (c), diabetic retinopathy (DR) (d) and cardiovascular disease (CVD) (e). Each subtype was compared to diabetes-free controls using logistic regression adjusted for sex and PCs. ANDIS (nSAID = 452, nSIDD = 1,193, nSIRD = 1,129, nMOD = 1,374, nMARD = 2,861, nT2D = 7,676, ncontrols = 2,744), and DIREVA (nSAID = 327, nSIDD = 394, nSIRD = 453, nMOD = 596, nMARD = 1,178, nT2D = 2,621, ncontrols = 1,683). In ANDIS, eGFR-GRS, UACR-GRS and CVD-GRS showed no association with any subtype. CKD-GRS was associated with SIRD with nominal significance in ANDIS (P = 0.047) but not in DIREVA (P = 0.38). DR was associated with SIRD (P = 0.016) and MOD (P = 0.015) with nominal significance but not in DIREVA (P = 0.37 and P = 0.36). None of the GRS were significant after adjustment for multiple comparisons (n = 5 tests). Data are presented as odds ratio and 95% confidence interval per s.d. increase of GRS. Exact numbers and statistics are in Supplementary Table 13. P-values are two-sided and not adjusted for multiple comparisons.

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