Table 1 Demographics, symptom severity, family history and associated conditions for IBS patients diagnosed via different modalities and with different IBS subtypes

From: Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders

 

Scores among DHQ participants completing the relevant sections

Among DHQ participants (%)

Atopy (%)

Group

n

Male (%)

Female (%)

Age (years)

Age (s.d.)

Mean IBS-SSS

Mean PHQ-12

Mean GAD-7

Family history of IBS

Childhood antibiotic exposure

Born by Cesarean section

Treatment for anxiety offered or sought

Treatment for depression offered or sought

Pooled asthma/hay fever/eczema

Controls (DHQ respondents)

72,356

50.3

49.7

65.3

7.5

33

4.0

1.5

9.5

9.6

2.5

16.1

18.0

18.1

Hospital ICD-10

4,237

23.4

76.6

65.9

7.9

202*

7.4*

3.6*

31.8*

24.0*

2.5

43.0*

43.6*

29.3*

Unprompted self-report

9,309

25.7

74.3

65.2

8.0

196*

7.1*

3.3*

30.7*

19.8*

2.3

41.1*

40.0*

29.6*

DHQ, Rome III criteria

24,845

27.9

72.1

63.9

7.7

194*

7.1*

3.3*

24.3*

20.4*

2.6

33.7*

35.1*

24.0*

DHQ, self-report

16,289

26.2

73.8

64.0

7.7

177*

6.9*

3.1*

29.0*

21.6*

2.7

39.7*

39.3*

25.9*

Pooled (any of the four definitions above)

40,548

27.9

72.1

64.3

7.8

173*

6.8*

3.1*

24.0*

20.0*

2.6

34.3*

35.2*

24.8*

DHQ, Rome III criteria, type C

3,989

16.9

83.1

64.5

7.8

190*

6.8*

3.2*

22.2*

19.2*

2.2

32.3*

34.1*

21.4*

DHQ, Rome III criteria, type D

6,506

33.2

66.8

63.8

7.7

185*

6.5*

3.0*

23.8*

19.1*

2.8

32.1*

33.0*

24.0*

DHQ, Rome III criteria, type M

13,666

28.5

71.5

63.8

7.8

204*

7.5*

3.6*

25.6*

21.5*

2.6

35.2*

36.9*

24.8*

DHQ, Rome III criteria, type U

672

31.0

69.0

65.6

7.5

124*

5.6*

2.4*

16.7*

17.7*

2.8

27.5*

24.9*

23.8*

DHQ, postinfectious

860

24.2

75.8

62.2

7.8

196*

7.4*

3.6*

30.3*

27.7*

3.5

42.0*

42.4*

26.6*

DHQ, functional constipation

3,502

33.9

66.1

67.1

7.4

64*

4.7*

1.8*

12.5*

11.0

2.5

23.1*

25.4*

19.0

DHQ, functional diarrhea

5,386

61.0

39.0

65.1

7.5

49*

4.3*

1.8*

11.0*

10.7*

2.6

20.3*

22.0*

20.5*

  1. Digestively healthy controls and functional constipation as well as diarrhea groups are shown for reference. Gastrointestinal symptoms are captured by the IBS-SSS (range 0–500), while somatic symptoms are captured by the (modified) PHQ-12 (range 0–22). The GAD-7 score captures symptoms of anxiety (range 0–21). The single asterisk marks significant differences from the control group after adjusting for age, sex, DHQ participation and (Bonferroni) multiple testing at P < 0.05/108 (two-sided logistic regression test). Age and sex differences were not tested.
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