Extended Data Fig. 3: deepHaem prediction of de novo open chromatin elements.
From: Identification of LZTFL1 as a candidate effector gene at a COVID-19 risk locus
deepHaem19 negative damage scores, which predict gain-of-accessibility, for the 28 candidate COVID-19 severity variants in 694 cell-types. Positive scores (loss-of-function) were adjusted to zero. In general, variants generating de novo regulatory elements33 have scores lower than -0.1, which was not true for any variant in any cell type.
