Extended Data Fig. 4: Mutation rates of missing drivers assuming different fitness effects.
From: Synonymous mutations reveal genome-wide levels of positive selection in healthy tissues
(a) The higher the fitness effects of the unobserved drivers, the lower the mutation rate needed to explain the discrepancy in the synonymous VAF density. Inset: Pie chart showing the fraction of explained, unexplained positive selection by observed drivers (all nonsynonymous SNVs on the panel15) and developmental contribution to the observed synonymous VAF spectra. (b) The observed synonymous VAF spectra (data points, variant number = 344) compared to the density predicted by observed drivers and developmental mutations (dashed orange line) and the predicted density by also including unobserved drivers with different fitness effects (solid orange lines). Data are presented as mean values ± sampling error.
