Extended Data Fig. 5: Contribution from different parts of the DFE to the predicted passenger spectrum.
From: Synonymous mutations reveal genome-wide levels of positive selection in healthy tissues
(a) The age distribution of the 4160 individuals in Bolton et al.15. (b) The predicted passenger spectrum in healthy blood according to the inferred distribution of fitness effects in healthy blood (Supplementary note 3C, ‘p = 3’) and best-fit total driver mutation rate from the synonymous VAF spectrum in blood (Supplementary note 3E) for the age distribution of the 4160 individuals. (c) The relative contribution to the passenger spectrum of driver mutations with different fitness effects changes as the individual ages. The total (grey line) represents the passenger VAF spectrum contributed by all driver mutations whose fitness s > 3.5%, below which contribution to the passenger spectrum is very small.
