Extended Data Fig. 6: Nonsynonymous VAF spectra in Martincorena et al.
From: Synonymous mutations reveal genome-wide levels of positive selection in healthy tissues
(a) The nonsynonymous VAF spectra of the top 10 genes (ranked by nonsynonymous SNV occurrence) were analyzed based on N τ = 7800 (Supplementary note 4C) to estimate their respective fitness and mutation rates. The analysis treats the distribution of fitness effects as delta functions each with a single-valued mutation rate and fitness, taking into account developmental contribution and possible passengers among nonsynonymous SNVs. (b) The nonsynonymous VAF spectra of genes beyond the top 10 (ranked by nonsynonymous SNV occurrence) were analyzed based on the chosen DFE (Supplementary note 3C). Similarly, developmental contribution and possible passengers among nonsynonymous SNVs were taken into account. Data are presented as mean values ± sampling error.
