Extended Data Fig. 2

Reversible and irreversible PRC2 targets are similarly enriched in gene ontology terms related to development. a, Left, top 10 most highly enriched gene ontology (GO) terms among genes whose transcription start site overlaps an H3K27me3 peak in NPCs, using all mouse genes as background. Right, top 10 most highly enriched GO terms among reversible and irreversible genes in NPCs, respectively, as indicated, using all mouse genes as background. p-values were calculated using a one-sided hypergeometric test and adjusted for multiple comparisons using the false discovery rate (FDR) method. b, As in a but for iMEF B subjected to transient PRC2i treatment (middle panels) or Ezh2 deletion and rescue (right panel, no significantly enriched GO term was found for reversible genes). PRC2i, PRC2 inhibition with 2 µM UNC1999 and 4 µM A-395. c, As in a, but for iMEF A.