Extended Data Fig. 4: Analysis of proximity between meQTL SNPs and CpGs. | Nature Genetics

Extended Data Fig. 4: Analysis of proximity between meQTL SNPs and CpGs.

From: Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function

Extended Data Fig. 4

Panel a: Histogram showing for each CpG site the genomic distance between CpG and the closest associated SNP from the cosmopolitan set of 10,346,172 SNP-CpG pairs identified in cis (association confirmed in both Europeans and South Asians). Panel b: Boxplots showing the proportion of SNP-CpG pairs that reach genome-wide significance for different distance categories (x-axis), compared to SNP-CpG pairs on different chromosomes (trans).1,000 random samples of 10,000 SNPs were taken. P-values above each box are based on a comparison (one-sided t-test) between the proportion of SNP-CpG pairs in trans that reach significance, and the proportion that reach significance in the respective same-chromosome distance window. Boxplots show medians (center lines), first and third quartiles (lower and upper box limits, respectively), 1.5-fold interquartile ranges (whisker extents) and outliers (black circles).

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