Fig. 1: Single-cell profiling of the human uterus.
From: Mapping the temporal and spatial dynamics of the human endometrium in vivo and in vitro
a, Schematic illustration of the human uterus showing the different layers and the morphological changes seen throughout the menstrual cycle with respect to tissue sampling. b, UMAP projections of scRNA-seq data from a total of 15 individuals. c, UMAP representations colored by menstrual phase. d, UMAP of subclustered immune populations. e, UMAP projections of snRNA-seq data from a total of four individuals in the proliferative phase. f, Radial representation of the cosine distance similarity for single cells obtained from snRNA-seq to the centroids of cell types defined by scRNA-seq. g, Estimated amount of mRNA (color intensity) contributed by each cell population to each spot (color) shown over the hematoxylin and eosin (H&E) image of the secretory endometrium (A30, 152811 slide). h, Dot plot showing log2-transformed expression of genes expressed in fibroblast and stromal subsets. i, Estimated amount of mRNA (color intensity) contributed by each cell population to each spot (color) shown over the H&E image of proliferative (A30, 152810 slide) and secretory (A30, 152811 slide) endometrium. Art, artery; DC, dendritic cell; fibro, fibroblast; Gland, glandular; ILC, innate lymphoid cell; Lymph, lymphoid; Lumen, lumenal; Mac, macrophage; PV, perivascular; T, T cell; uM, uterine macrophage; uNK, uterine natural killer cell; uSMC, uterine smooth muscle cell.
