Extended Data Fig. 6: Expression of epithelial markers in endometrial disorders.
From: Mapping the temporal and spatial dynamics of the human endometrium in vivo and in vitro
a, Volcano plot showing upregulation of markers specific for SOX9 + LGR5 + in endometrial tumours with a SOX9 + LGR5 + signature in comparison with those with a SOX9 + LGR5- signature. Negative log fold changes similarly show the opposite pattern where markers are characteristic of the SOX9 + LGR5- population instead. b, Boxplots showing expression levels of epithelial marker genes in endometrium and peritoneum from patients with endometriosis from GSE141549. Expression in peritoneal lesions is compared to endometrium and peritoneum with two-sided Wilcox test (ns; not significant: p > 0.05). Box plots represent quartiles and whiskers extend up to 1.5 IQR beyond each box to encapsulate extrema. For the proliferative and secretory comparisons, the number of independent biological samples was, respectively: control endometrium (n = 17 and n = 25), control peritoneum (n = 4 and n = 8), peritoneal red lesions (n = 2 and n = 7), peritoneal white lesions (n = 5 and n = 4) and peritoneal black lesions (n = 6 and n = 5). E Pat = endometrium (patient); P Pat = non-lesional control Peritoneum (Patient); P lesion R = Peritoneal Lesion Red; P lesion W = Peritoneal Lesion White; P lesion B = Peritoneal Lesion Black.
