Fig. 5: Interrogation by CellPhoneDB v.3.0 of ligands and receptors mediating epithelial differentiation.
From: Mapping the temporal and spatial dynamics of the human endometrium in vivo and in vitro
a, Adaptation of our cell–cell communication tool that considers spatial cellular dynamics and is available at https://github.com/Ventolab/CellphoneDB. b, Schematic illustration of receptors and ligands involved in WNT and NOTCH signaling. c, Dot plots showing expression of CellPhoneDB v.3.0 relevant ligands in epithelial, stromal and fibroblast populations with cognate receptors in epithelial subsets. Only significant interactions (fold change > 0.02 and FDR < 0.005) are represented. The color of the arrows corresponds to the pathways whose ligand–receptor partners are involved, as shown in b. d, Estimated proportions of DKK1 in the early-proliferative phase (A30, 152807 slide). e, Schematic illustration of our proposed model for temporal and spatial distribution of epithelial and stromal subsets across the menstrual cycle. The proliferative phase is dominated by a WNT environment that promotes regeneration. Compartmentalization of WNT and NOTCH signaling during the secretory phase promotes efficient differentiation toward the ciliated and secretory lineages.
