Table 3 LDSC-SEG results that are significant at FDR 5%
Tissue/cell type and histone mark | Tissue category | P value | FDR adjusted P value |
|---|---|---|---|
Multitissue gene expression data | |||
Aorta | Cardiovascular | 1.78 × 10–4 | 0.029 |
Tibial artery | Cardiovascular | 3.60 × 10–4 | 0.029 |
Coronary artery | Cardiovascular | 4.29 × 10–4 | 0.029 |
Gene expression data of 13 brain regions from GTEx | |||
Caudate (basal ganglia) | CNS | 6.00 × 10–4 | 0.008 |
Multitissue chromatin annotation data | |||
Fetal brain female, H3K4me3 | CNS | 2.49 × 10–5 | 0.012 |
Brain dorsolateral prefrontal cortex, H3K27ac | CNS | 8.43 × 10–5 | 0.018 |
Brain dorsolateral prefrontal cortex, H3K4me3 | CNS | 1.11 × 10–4 | 0.018 |
Aorta, H3K4me1 | Cardiovascular | 2.57 × 10–4 | 0.031 |
Stomach mucosa, H3K36me3 | Digestive | 3.36 × 10–4 | 0.032 |
Aorta, H3K27ac | Cardiovascular | 4.40 × 10–4 | 0.032 |
Artery-tibial ENTEX, H3K4me1 | Cardiovascular | 4.53 × 10–4 | 0.032 |
Ganglion eminence derived primary cultured neurospheres, H3K4me3 | CNS | 6.53 × 10–4 | 0.04 |
Brain germinal matrix, H3K4me3 | CNS | 8.42 × 10–4 | 0.043 |
Aorta ENTEX, H3K27ac | Cardiovascular | 1.11 × 10–3 | 0.043 |
Artery-coronary ENTEX, H3K4me3 | Cardiovascular | 1.13 × 10–3 | 0.043 |
Cortex derived primary cultured neurospheres, H3K36me3 | CNS | 1.14 × 10–3 | 0.043 |
Ovary, H3K27ac | Other | 1.15 × 10–3 | 0.043 |
Cortex derived primary cultured neurospheres, H3K4me3 | CNS | 1.29 × 10–3 | 0.045 |
Aorta ENTEX, H3K4me1 | Cardiovascular | 1.39 × 10–3 | 0.045 |
Stomach smooth muscle, H3K4me3 | Musculoskeletal/connective | 1.55 × 10–3 | 0.047 |
