Extended Data Fig. 1: Developmental transcription factor gene enrichment. | Nature Genetics

Extended Data Fig. 1: Developmental transcription factor gene enrichment.

From: Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility

Extended Data Fig. 1

In 10,000 simulations of 12 SNP sets matching the non-chromosome 3 BrS lead SNPs (permutation-based unilateral (one-sided P-value) enrichment test), no more than six DNA binding protein genes were located within 300 kb (range: 0-6 genes). In contrast, among the 12 non-chromosome 3 lead SNPs, 10 overlapped or were located within 300 kb of DNA binding protein genes (P = 1 × 10−4). DNA binding protein genes were defined according to number of Gene Ontology: 0043565.

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