Extended Data Fig. 3: Cellular electrophysiology studies in MAPRE2 knockout and control hiPSC-CMs. | Nature Genetics

Extended Data Fig. 3: Cellular electrophysiology studies in MAPRE2 knockout and control hiPSC-CMs.

From: Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility

Extended Data Fig. 3

Typical current recordings and (in)activation properties in control (CTRL) human induced pluripotent stem cell derived cardiomycytes (hiPSC-CMs) and without MAPRE2 (MAPRE2 KO). a, Typical sodium current (INa) in a CTRL and MAPRE2-KO hiPSC-CM. b, Voltage-dependency of activation (squares) and inactivation (circles) in CTRL and MAPRE2 KO hiPSC-CMs. The V1/2 of voltage dependency of activation was 4.2 mV more positive (P = 0.0016) in MAPRE2 KO compared with CTRL hiPSC-CMs. c, Recovery from inactivation in CTRL and MAPRE2 KO hiPSC-CMs. d, Typical repolarizing outward currents (IOutward) in a CTRL and a MAPRE2 KO hiPSC-CM. e, Voltage-dependency of IOutward activation in CTRL and MAPRE2 KO hiPSC-CMs. CTRL, control; KO, knock-out. Data in b, c, and e are presented as mean values ± s.e.m. Statistical test used was two-sided unpaired t-test.

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