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Discovering missing heritability in whole-genome sequencing data

Nature Genetics volume 54, pages 224–226 (2022)Cite this article

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The gap between heritability estimates from twin studies and those from genotyping array data has puzzled researchers for over a decade. New research suggests that much of the ‘missing’ heritability is due to rare variants that can only be captured by whole-genome sequencing (WGS) data.

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Fig. 1: How mutations give rise to common and rare variants.

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Authors and Affiliations

  1. Human Genetics Department, UCLA David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA

    Alexander I. Young

  2. UCLA Anderson School of Management, Los Angeles, CA, USA

    Alexander I. Young

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  1. Alexander I. Young
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Correspondence to Alexander I. Young.

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Young, A.I. Discovering missing heritability in whole-genome sequencing data. Nat Genet 54, 224–226 (2022). https://doi.org/10.1038/s41588-022-01012-3

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