Fig. 5: Systematic nomination of candidate key TFs for cell-type specification.
From: Systematic reconstruction of cellular trajectories across mouse embryogenesis
a, We heuristically defined candidate key TFs as those that are expressed in the pseudoancestral cell state, are significantly upregulated in the newly emerged cell type and are not significantly upregulated at any sister edges. b, Histogram of the number of candidate key TFs for each cell type at the time point of its first emergence. c, The histogram of the number of cell types in which each TF was nominated as a candidate key TF. d, Diagram illustrating selected cellular trajectories from TOME, decorated with the top five scoring candidate key TFs for each edge. AER, apical ectodermal ridge. Style inspired by Morris et al.98.
