Fig. 1: COVID-19 Continuous_Severity_Score captures multiple aspects of symptom severity among COVID-19+ individuals. | Nature Genetics

Fig. 1: COVID-19 Continuous_Severity_Score captures multiple aspects of symptom severity among COVID-19+ individuals.

From: Expanded COVID-19 phenotype definitions reveal distinct patterns of genetic association and protective effects

Fig. 1

The Continuous_Severity_Score was derived from the first principal component across nine survey fields related to COVID-19 clinical outcomes, including three symptoms, hospitalization, ICU admittance and other severe complications due to COVID-19 illness (Methods). Plots reflect mean symptom severity (top three panels) or prevalence (bottom three panels) for several fields as a function of ascending Continuous_Severity_Score decile. Symptom information was encoded as follows: 0 = none, 0.2 = very mild, 0.4 = mild, 0.6 = moderate, 0.8 = severe and 1.0 = very severe. A paucisymptomatic case corresponds to an individual reporting symptoms of mild intensity or less. Squares represent the estimate, and error bars represent the 95% confidence intervals (CIs) for each estimate (n = 4,952 biologically independent samples).

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