Extended Data Fig. 3: CCL22-Pro79Arg transduced NK-92 recapitulated primary CLPD-NK samples with CCL22 mutations in the expression of several important genes. | Nature Genetics

Extended Data Fig. 3: CCL22-Pro79Arg transduced NK-92 recapitulated primary CLPD-NK samples with CCL22 mutations in the expression of several important genes.

From: CCL22 mutations drive natural killer cell lymphoproliferative disease by deregulating microenvironmental crosstalk

Extended Data Fig. 3

a, Gene expression ratio of CCL22-Pro79Arg NK-92 cells compared to CCL22-wild type (wt) and empty vector (EV)- transduced NK-92 cells. b, Reduced FASLG expression of CCL22-Pro79Arg NK-92 cells compared to CCL22wt and EV NK-92 cells was confirmed by flow cytometry. CCL22-Pro79Arg NK-92 cells without staining is shown as Negative. c, Immunoblotting confirmed higher GZMK expression in engrafted CCL22-Pro79Arg NK-92 cells. The samples derive from the same experiment and were processed in parallel.

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