Extended Data Fig. 5: Dnmt3a1ΔN mice showed a reduced rate of weight gain and impaired behaviors.
a, Body weights of female Dnmt3a1ΔN (n = 5) mice and WT littermates (n = 5) at the age of 2, 4 and 6 months. Data are shown as mean ± s.d. ** P = 0.003166; *** P = 0.000360; **** P < 0.0001 (multiple t tests). b, Representative images of Dnmt3a1ΔN and WT females at 6 months. c, Dnmt3a1ΔN mice exhibited an increase in fecal boli deposits during 30-min open field test. **** P < 0.0001 (two-sided unpaired t tests). d, Dnmt3a1ΔN mice showed a similar level of anxiety with WT littermates in a Light-dark exploration test. ns: not significant (two-sided unpaired t tests), dark duration, P = 0.5814; light duration, P = 0.5810; entries, P = 0.4214. The number of mice analyzed in c,d: Dnmt3a1ΔN, n = 19; WT, n = 16. Data are shown as mean ± s.e.m. with individual values.
