Extended Data Fig. 8: Co-accessibility and gene regulatory analyses prioritize transcriptional regulators TBX2 and PRDM16. | Nature Genetics

Extended Data Fig. 8: Co-accessibility and gene regulatory analyses prioritize transcriptional regulators TBX2 and PRDM16.

From: Single-nucleus chromatin accessibility profiling highlights regulatory mechanisms of coronary artery disease risk

Extended Data Fig. 8

(a) Genome browser track highlighting the association between CAD associated SNPs and SMC marker genes through co-accessibility (peak2gene) detected by snATAC-seq data (Methods). The red loops represent the association between TBX2 promoter and CAD associated SNPs. (b) Network visualization of TBX2 key driver target genes in STARNET atherosclerotic aortic root (AOR) tissue. (c) Clinical trait enrichment for PRDM16 module 28 in STARNET liver tissue. (d) Network visualization of PRDM16 key driver target genes in STARNET mammary artery (MAM) and liver tissues.

Back to article page