Extended Data Fig. 10: Epigenetic domains comparison between zebrafish and mouse.

a, Comparison of sizes of genomic sequences covering orthologous GRB-containing TADs. TADs are ranked by size, largest on top. b, Schematic illustration of the projection of an example genomic location X between zebrafish and mouse by interpolation using the direct alignments (grey rectangles) and the alignments via a bridging species (blue and red rectangles, Xenopus in this example). projections are indicated as a black X in the respective species). Dashed lines connect pairwise sequence alignments. The projected locations of X in mouse are indicated in grey (direct alignments) and black (via bridging species). c, Example graph comprising 15 species (nodes). For any genomic location, the shortest path through the species graph yields the combination of species which maximizes projection accuracy. d, H3K27me3 overlap profiles of all GRB TADs. TADs are ordered by their relative amount of shared signal. Bins are in the original genomic order. e, Fractions of bins with shared or species-specific H3K27me3 enrichment. Bins are classified as alignable (n=22,403) if they overlap a direct sequence alignment between zebrafish and mouse and as non-alignable otherwise (n=97,767). P-values are obtained by Fisher’s exact test.