Fig. 1: Study schema.

For each of the five cohorts, the number of patients, anatomical locations and the number of samples profiled using scRNA-seq are indicated at the top. The major stages of data analysis are indicated below and to the right. For each cohort, the total number of profiled cells and the number of epithelial cells are indicated at the bottom. Single-cell transcriptomes from the SMC cohort and six patients from KUL3 (75,332 cells in all after QC) have been previously reported9.