Extended Data Fig. 2: Sub-clustering of all major cell type in CRC-SG1 cohorts.

a. (Left) UMAP visualization of clusters representing major cell types in CRC-SG1 (n = 208,367), (Right) Epithelial sub-cluster colored by cluster ID, tumor sectors, and sample ID (n = 15,920). b. UMAP visualization of B (n = 19,088 cells), Plasma-B (n = 26,710 cells), Endothelial (n = 6,875 cells), monocyte conventional dendritic cell (McDC) (n = 26,127 cells), Fibroblast (n = 31,415 cells), and T and NK (T_NK) (n = 76,812 cells) subclusters from 14 patients in CRC-SG1 dataset, colored by tumor sectors (upper panel), patient ID (middle panel), and sample ID (lower panel).