Extended Data Fig. 10: Comparison of metagene signature of selected histology, cell types & states of the colon (A) and drug response signatures (B) in single cell epithelial cells across iCMS classes. | Nature Genetics

Extended Data Fig. 10: Comparison of metagene signature of selected histology, cell types & states of the colon (A) and drug response signatures (B) in single cell epithelial cells across iCMS classes.

From: Single-cell and bulk transcriptome sequencing identifies two epithelial tumor cell states and refines the consensus molecular classification of colorectal cancer

Extended Data Fig. 10

Box plots of metagene scores comparing iCMS2 (n = 35) versus iCMS3 (n = 23) in patient-specific pseudo-bulk. Within the iCMS3 group, i3-MSI (n = 10) samples are labelled by red jitter points and i3-MSS samples are labelled by orange jitter points. The metagene scores for each patient pseudo-bulk was calculated by averaging the scaled expressions of all genes in the geneset in the given patient. P-values were calculated by two-sided Wilcoxon rank-sum test. Center line indicate the median, and box edges indicate the 25th (Q1) and 75th (Q3) percentiles. Whiskers are plotted at 1.5xIQR and data beyond the end of the whisker are outliers.

Back to article page