Extended Data Fig. 2: CLL biological pathways affected by candidate driver genes.
From: Molecular map of chronic lymphocytic leukemia and its impact on outcome
a. Schema of CLL pathways containing previously identified (black) and novel (magenta) putative driver genes (see Supplementary Table 6). Novel drivers cluster in central processes driving CLL (for example, DNA damage, chromatin modification, RNA processing)1,2, but also highlight new pathways not previously implicated by driver genes (for example, cytoskeleton and extracellular matrix, proteostasis, metabolism). Asterisks - mutated genes discovered by CLUMPs. b. Stacked barplot ranked by the number of candidate driver genes per CLL pathway. Magenta bars show the number of newly identified drivers in each pathway.
