Extended Data Fig. 7: gene and enhancer eQTL.
From: Population-level variation in enhancer expression identifies disease mechanisms in the human brain
a, Percentage of genes/enhancers that are cis-heritable (GCTA nominal P < 0.05 and cis-heritability > 0). b, Overlap of cis-heritable genes between ACC and DLPFC. c, Overlap of cis-heritable enhancers between ACC and DLPFC. d, Dot plots illustrate the first two genetic ancestry principal components (PCs) for individuals reported (report) to have European ancestry and the individuals selected (select) to have European ancestry based on sd to the center. e, The replication of eQTL from the discovery set in the replicate set across different P value cutoffs for the discovery set. π1 values (proportion of true positive p values) for the discovery set significant eQTL in our replicate eQTLs. SCC values are the Spearman correlation coefficients of significant eQTL effect sizes between the two sets. f, The percentage of genes/enhancers that have significant eQTL are cis-heritable across different P value cutoffs. Overlap of the cis heritable transcript with the transcript with eQTL for genes g, and h, enhancer.
