Extended Data Fig. 1: TEns identification.
From: Population-level variation in enhancer expression identifies disease mechanisms in the human brain
a, The distribution of deconvolved RNA-seq cell type distribution for each sample (Nneuron = 47, Nnon-neuron = 46). Box plot indicates median, interquartile range (IQR) and 1.5 × IQR. b, Jaccard index between the Multi-omics peaks and previous reports. cell-type-specific ATAC-seq/H3K4me3/H3K27ac peaks were compared to our previous reports of the corresponding assays9,110. H3K27me3 was compared to Roadmap H3K27me3 peaks23. PFC indicates the prefrontal cortex. c, Empirical density distribution of FANTOM5 enhancer size; based on the curve, we chose 500 bp as the TEn size. d, Feature importance heatmap from random forest models. e, Distribution of TEn numbers per super-enhancer in the two cell types (Nneuron = 2,049, Nnon-neuron = 1,946). Box plots as in a. f, Distance to the nearest TEns for every TEn within or outside of super-enhancer regions (Nneuron = 29,555, Nnon-neuron = 23,260, P < 10−16 for both cell types, two-sided Wilcoxon test). Box plots as in a. g, Epigenomic profiles of expressed TEns, and promoters of protein-coding genes and lincRNAs. The line represents the mean, and the shadow indicates a 95% confidence interval.
