Extended Data Fig. 3: Differential expression/activity between neuronal and non-neuronal cells.
From: Population-level variation in enhancer expression identifies disease mechanisms in the human brain
a, ChromHMM identified 6 chromatin states including EnhA (active enhancer), TssA (active promoters), TssBiv (bivalent promoters), TssFlnk (promoter flanking region), ReprPC (polycomb repression region), and Quies (other regions). b, Comparing the cell-type-specific Chromatin states with the roadmap DLPFC result. c, Jaccard index between neuronal and non-neuronal chromatin states. Compared to active promoters (TssA), and polycomb repressed regions (ReprPC), active enhancers (EnhA) are remarkably more different between cell types. d, Overlap of expressed TEns between neuronal and non-neuronal cells. e, π1 statistics of differential activity between the two cell types of different molecular markers. f, Violin plot shows the variance explained by different factors for the five markers (NATACSeq = 98, NTEns = Ngene = 93, NH3K27ac = 96, NH3K4me3 = 96). Box plot indicates median, interquartile range (IQR), and 1.5 × IQR.
