Fig. 1: Q–Q plots for Burden, SKAT and SKAT-O for four exemplary binary phenotypes in UKBB WES data using SAIGE-GENE and SAIGE-GENE+. | Nature Genetics

Fig. 1: Q–Q plots for Burden, SKAT and SKAT-O for four exemplary binary phenotypes in UKBB WES data using SAIGE-GENE and SAIGE-GENE+.

From: SAIGE-GENE+ improves the efficiency and accuracy of set-based rare variant association tests

Fig. 1

a, SAIGE-GENE. b, SAIGE-GENE+. Burden, SKAT and SKAT-O tests were performed for 18,372 genes with missense and LoF variants with three different maximum MAF cutoffs (1%, 0.1% and 0.01%). Names of genes reaching the exome-wide significance threshold (two-sided P < 2.5 × 10−6) in SAIGE-GENE+ are annotated in the plots.

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