Extended Data Fig. 5: Human circulating tumour cells (CTCs) and peripheral blood mononuclear cells (PBMCs).
From: The NALCN channel regulates metastasis and nonmalignant cell dissemination
(a) UMAP of single cell RNA sequencing (SCS) profiles of human CTCs and PBMCs (see main text for SCS sources). Genesets enriched in the indicated SCS clusters are shown with adjusted p-value for enrichment in parenthesis. (b) Heatmap of indicated gene expression from relevant genesets enriched in each cell from each cluster in (a). (c) Feature plots of exemplar genes enriched in human CTCs in (a). (d) Mouse orthologues of human genes in (c) mapped onto the UMAP of mouse CZCs and PBMCs in main Fig. 3b. (e) UMAPs of SCS profiles of common orthologues expressed in human CTCs and mouse tCZCs. (f) Enrichment of haemoglobin gene expression in UMAP shown in (e). (g) Geneset enrichments in the dotted-line enclosed, central cluster relative to the other SCS profiles is reported in (e).
