Extended Data Fig. 2: Histological appearance of islets from HK1-CHI and ABCC8-HI tissue. | Nature Genetics

Extended Data Fig. 2: Histological appearance of islets from HK1-CHI and ABCC8-HI tissue.

From: Non-coding variants disrupting a tissue-specific regulatory element in HK1 cause congenital hyperinsulinism

Extended Data Fig. 2

Panels a and b illustrate islets from two HK1 CHI patients (patients 1 and 6 Supplementary Table 2) in comparison to age-matched tissue from ABCC8 CHI patients with diffuse pancreatic disease (c, d). The yellow dashed line delineates a single islet in each sample. Nuclear enlargement (B, arrowhead) and nucleomegaly (C, D arrows) was virtually undetected in control islets (n = 12/72,145 islet cells) but found in 0.8% of HK1 islets (n = 374/46,885 cells) and 4.9% of ABCC8 islet cells (n = 70,929). Inserts illustrate the corresponding haematoxylin and eosin images. Scale bar 50 µm.

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