Fig. 3: Convergent CTCF sites further constrain polymer dynamics.
From: Cohesin and CTCF control the dynamics of chromosome folding
a, Simulated contact maps of a region spanning the equivalent of 800 kb for a polymer chain without loop extrusion, with loop extruders and with convergent extrusion barriers separated by the equivalent of 152 kb. b, Radial MSD of the two monomers separated by the equivalent of 152 kb in the three conditions from panel a. Dashed line is an exponent of 0.2 as a guide to the eye (αr indicates the slope of radial MSDs). Loop extrusion parameters as in Fig. 2c. c, Representative examples of distances between the two monomers in simulations with or without loop extrusion and extrusion barriers. The flat stretch in the trajectory with extrusion and barriers corresponds to a loop anchored by the two barriers.
