Extended Data Fig. 3: Simulations of chromosome dynamics and effects of loop extrusion.
From: Cohesin and CTCF control the dynamics of chromosome folding
A. Visual comparison of experimental Hi-C contact map with contact maps of simulations at extrusion speed 1 kb/s, extruder loading rate 0.06 (Mb x min)−1 and residence time 5.5 min. B. Contact maps for the polymer simulations at extrusion speed 0.1 kb/s and barriers from the range 7–16 Mb of chromosome 15. Acronyms used in this figure are indicated in the black box on the right. C. Pairwise comparison for conditions indicated in the title of each pair of heatmaps. Pair of heatmaps contains ratios of generalized diffusion coefficients (D) and scaling exponent (α), and represents fold change between the conditions.
