Extended Data Fig. 4: Cross-ancestry comparison.

a, Comparison of allele frequencies between the meta-analysis and Biobank Japan. Black dots denote the allele frequencies for 199 sentinel variants reaching genome-wide significance in the (predominantly European ancestry) meta-analysis (y-axis) that were also present in the publicly available summary statistics from Biobank Japan (x-axis). Variants were aligned according to the effect allele in Supplementary Table 3. The Pearson correlation coefficient was 0.76. b, Comparison of beta estimates between the meta-analysis and Biobank Japan. Black dots denote the beta estimates for the CAD associations for 199 sentinel variants reaching genome-wide significance in the (predominantly European ancestry) meta-analysis (y-axis) that were also present in the publicly available summary statistics from Biobank Japan (x-axis). Variants were aligned according to the effect allele in Supplementary Table 3. Horizontal and vertical lines represent 95% confidence intervals. The Pearson correlation coefficient was 0.59, which increased to 0.85 when three outlying variants marked in red (at ATXN2, FER and SLC22A1) were excluded.