Fig. 2: Polygenic prediction of incident and recurrent CAD. | Nature Genetics

Fig. 2: Polygenic prediction of incident and recurrent CAD.

From: Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants

Fig. 2

a,b, Prognostication of incident CAD (a) and recurrent coronary events (b) by optimal PRS derived from the current meta-analysis of ~180 K CAD cases (2022 PRS; includes ~2.3 million variants) or a previously reported GWAS meta-analysis of CAD from 2015 involving ~60 K CAD cases (2015 PRS; includes ~1.5 million variants). We analyzed 815 incident events in the validation subset of the MDC Study and 1,074 recurrent coronary events in the FOURIER trial. Cox proportional hazards models were adjusted for age, sex and genetic principal components.

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