Extended Data Fig. 9: Simulations reveal that it is difficult to assign alleles to particular trajectories.
From: Dietary stress remodels the genetic architecture of lifespan variation in outbred Drosophila
Loci were simulated to follow one of three possible trajectories: (A) allele decreases at a constant rate across all ages; (B) allele decreases in frequency early in life but increases again in late life; or (C) allele is maintained at a constant frequency up to a given age but then steadily declines. These simulations were performed for datasets with allele frequency changes between T0 and TN ranging from 0-20% (x-axis). Details of the statistical model are described under section S8. All loci were then analyzed using models that capture all three possible trajectories, and the ΔAIC value between the best fit model and the second-best fit model was calculated for each locus (y-axis). Dashed red lines represent a ΔAIC value of 2. (Boxplot edges are the 25th and 75th percentiles, the center line is the median and whiskers are at 1.5 the interquartile range).
