Extended Data Fig. 8: Magnitude of neoantigen depletion according to the predicted immunogenicity of class II neoantigens.
From: MHC II immunogenicity shapes the neoepitope landscape in human tumors
According to contrasting terms, namely, a, TCR richness versus TCR evenness and b, Th1 cells versus Th2 cells, the distributions of VAFs comparing immunogenic and nonimmunogenic mutations were plotted for DeepNeo and NetMHCpan. The differential distribution between the two types of variants were estimated using Kolmogorov’s D statistic.
